ILLUMINATE-C is an open-label study to evaluate the safety and effectiveness of lumasiran (ALN-GO1) in people with Advanced Primary Hyperoxaluria Type 1 (PH1) patients both on and off dialysis.
This study will include 2 cohorts (groups):
- Cohort A: Non-dialysis patients
- Cohort B: Dialysis-dependent patients
If dialysis is initiated after joining the study, participation can continue. Patients from cohort A can cross to cohort B if dialysis is initiated after joining the study.